Matthias Mann

Professor Matthias Mann is Research Director and Group leader at the Proteomics Program at Novo Nordisk Foundation Center for Protein Research (CPR) at the University of Copenhagen's Faculty of Health and Medical Sciences. He also holds a Director position at the Max-Planck Institute of Biochemistry in Munich. As one of the most highly cited researchers in the world with h-index 216 and over 200,000 citations, Mann is a pioneer of mass spectrometry-based proteomics who has made landmark contributions to the development of electrospray ionization.

Professor Mann's research interests focus on proteomics technology development and its application to biological and clinical problems. His Clinical Proteomics group applies mass spectrometry-based proteomics to understand human health and disease, with the goal of improving patient diagnosis, stratification, and prevention of diseases such as metabolic disorders and cancer. The group has established robust, high-throughput proteome profiling pipelines for clinical cohorts and develops AI-guided platforms for analyzing proteomes from low amounts of formalin-fixed, paraffin-embedded samples. A key research area is the interpretation of multi-omics data through the Clinical Knowledge Graph, which harmonizes multi-omics data with meta-data for machine learning applications.

Professor Mann's recent publications demonstrate trends across several fields including clinical proteomics, biomarker discovery, mass spectrometry technology development, and multi-omics integration. His work spans applications in cancer research, metabolic diseases, neuroscience, and cardiac biology, with a consistent focus on translating proteomic technologies into clinical applications for personalized medicine.

• Dr H.P. Heineken Prize for Biochemistry and Biophysics 2024
• Louis-Jeantet Foundation Prize for Medicine (2012)
• Leibniz Prize of the German Research Society (2012)
• Körber European Science Award (2012)
• Ernst Schering Prize (2012)
• Protein Society Anfinsen Award (2005)
• Novo Nordisk Prize (2004)

Professor Mann has mentored numerous researchers, with several former post-docs receiving prestigious ERC Starting Grants. His research has been supported by significant funding from the Novo Nordisk Foundation and other major research organizations. The Mann Group maintains collaborations with clinical researchers across multiple institutions to apply proteomics to patient cohorts and disease studies.

The Mann Group operates within the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen, working closely with other research groups including the Choudhary Group, Olsen Group, and others within the CPR. The group maintains state-of-the-art mass spectrometry facilities and develops computational tools for proteomic data analysis, creating an integrated environment for technological innovation and biological discovery.