Matthew Spinelli

Matthew Spinelli, MD, MAS is an Assistant Professor in the Department of Medicine at the University of California, San Francisco (UCSF). He is an HIV/ID physician with expertise in implementation science, focusing on PrEP adherence, HIV treatment retention, and doxycycline post-exposure prophylaxis (PEP). He leads projects using point-of-care urine tenofovir testing to improve adherence interventions. As the PrEP Medical Lead for UCSF's Ward 86 Clinic, he co-directs educational programs in implementation science. He collaborates with the SF Department of Public Health on health equity initiatives. His research spans HIV prevention, viral suppression, and pandemic responses. Notable roles include Principal Investigator on NIH grants for doxycycline PEP and long-acting injectable PrEP implementation.

Education and Training:

• B.A., Italian Literature, Columbia University
• M.D., Mount Sinai School of Medicine
• M.A.S., Epidemiology & Implementation Science, UCSF
• Fellowships: HIV Clinical & Research, Infectious Diseases, Internal Medicine (UCSF)

Research Interests: Spinelli’s work centers on optimizing HIV prevention and treatment through adherence strategies, leveraging implementation science to address disparities. Key areas include PrEP persistence, viral load monitoring, and integrating novel adherence tools like real-time urine assays. His studies highlight intersections of HIV and emerging health challenges like opioid use and long-COVID.

Grants & Projects:

• NIH R01AI186641: Randomized trial of doxycycline PEP
• NIH UG3DA058304: Cohort study on stimulant use and HIV suppression
• NIH R21AI167648: HIV and SARS-CoV-2 vaccine responses

Awards: None explicitly listed, though his NIH funding reflects recognition of his research impact.

Clinical & Educational Roles: Co-director of Implementation Science courses at UCSF, member of the Partnership for Research in Implementation Science for Equity, and PrEP Medical Lead at Ward 86.