Matthew Ryan Hassler

Matthew Ryan Hassler, PhD, is an Instructor at the RNA Therapeutics Institute within the T.H. Chan School of Medicine at UMass Chan Medical School. His research focuses on RNA interference (RNAi) and oligonucleotide delivery systems for therapeutic applications in neurodegenerative diseases.

• Education:
  • BA in Chemistry, University of Saskatchewan
  • PhD in Organic Chemistry, McGill University

Research Interests: Dr. Hassler specializes in optimizing small interfering RNA (siRNA) for gene silencing in diseases like ALS, Alzheimer's, and Huntington's. His work explores chemical modifications to enhance siRNA stability, targeting precision, and delivery efficiency via lipid conjugation and divalent scaffolds.

Publication Trends: Over 18 years, Dr. Hassler has contributed to 23 publications, primarily in Nature Biotechnology, Nucleic Acids Research, and Molecular Therapy journals. Key themes include RNAi efficacy, neurodegenerative disease models, and pharmacokinetic profiling of modified oligonucleotides.

Collaborations: Dr. Hass Jonathan Khvorova and Neil Aronin, with co-authorships in RNA Therapeutics Institute projects. His work has been cited over 450 times, with significant impact on siRNA design and delivery.