Matthew Gage

Matthew Gage, Ph.D., is a Professor at the University of Massachusetts Lowell and Director of the UMOVE Center. He holds dual affiliations with the Chemistry Department and the Center for Pathogen Research & Training (CPRT). His research focuses on understanding protein function, particularly the role of titin in muscle mechanics and structure. He has expertise in biophysical techniques, bioinformatics, and antimicrobial development.

Education: Ph.D. in Biochemistry and Molecular Biology (Purdue University, 2001), B.S. in Chemistry and Molecular Biology (University of Wyoming, 1996). Awards include the NIH Biophysics Training Grant and NSF REU Fellowship.

Research Interests:

• Titin structure-function relationships in muscle elasticity
• Protein unfolding mechanisms under mechanical force
• Bioinformatics-driven analysis of muscle gene expression
• Development of novel antimicrobial compounds

Key grants include NIH R15 funding for pH-responsive peptides and NSF support for linking genome to muscle phenome. His lab employs techniques like magnetic tweezers, RNA-Seq, and fluorescence-based assays.

Awards: Dean's List (Wyoming), multiple training grants, and recognition for undergraduate excellence.

Advising: Supervises graduate students in protein chemistry and biophysics. Active in interdisciplinary collaborations across muscle biology and drug discovery.