معرفی
Matthew Champion is an Associate Professor in the Department of Chemistry and Biochemistry at the University of Notre Dame, where he leads the Champion Laboratory. His research integrates biochemistry, proteomics, and genetics to investigate microbial pathogenesis, particularly in mycobacteria.
- Current Position: Associate Professor, University of Notre Dame (2019–present)
- Previous Academic Roles: Research Associate Professor (2015–2019), Research Assistant Professor (2009–2015), University of Notre Dame
- Industry Experience: Applied Biosystems (AB Sciex), Mass-Spectrometry-Proteomics Group (2003–2009)
- Education: Ph.D. in Biochemistry, Texas A&M University (2005); B.S. in Microbiology, University of Iowa (1997)
Champion's research focuses on microbial proteomics and metagenomics, with an emphasis on protein secretion systems in pathogenic bacteria like Mycobacterium tuberculosis. His lab develops antibody-free, proteogenetic assays to dissect the ESX-1 secretion system, a key virulence mechanism. He utilizes state-of-the-art quantitative proteomics, capillary electrophoresis, and genetic screening to identify and quantify secreted proteins involved in disease phenotypes. His work has broad applications in understanding bacterial virulence, antigen discovery, and therapeutic targeting.
His recent publications span analytical method development, microbial physiology, and systems biology. Trends in his research include innovation in capillary electrophoresis interfaces, streamlined proteomic workflows (e.g., MAP), and deep functional characterization of secretion hierarchies in mycobacteria. His studies frequently appear in high-impact journals such as Cell, PNAS, and Analytical Chemistry.
Dr. Champion has mentored numerous graduate students, including Dr. Daniel Hu, Dr. Taylor Lundgren, and Dr. Caitlin Kerr, who have successfully defended their dissertations. His lab actively participates in national conferences such as ASMS, and he contributes to the development of open tools like Skyline for proteomics data analysis.
The Champion Lab is part of the analytical and biochemistry divisions within the Department of Chemistry and Biochemistry, fostering interdisciplinary research at the intersection of biology, chemistry, and engineering. The lab maintains a dynamic environment with ongoing projects in microbial secretion, host-pathogen interactions, and analytical instrumentation.
