Matt Shotwell

Matt Shotwell is an Associate Professor in the Department of Biostatistics at Vanderbilt University School of Medicine, with a secondary appointment in Anesthesiology. He serves as Director of the Design & Analysis Unit at the Vanderbilt Biostatistics Data Coordinating Center (VBDCC), where he oversees methodological and collaborative research in clinical data analysis.

• PhD in Biostatistics from the Medical University of South Carolina

His research spans biostatistical methodologies applied to anesthesiology, critical care, and sleep medicine. Key areas include obstructive sleep apnea treatment via neuromodulation, mechanical ventilation optimization, cardiovascular outcomes in critical illness, and statistical frameworks for pandemic platform trials. His recent work focuses on oxygenation dynamics, pharmacogenetic-guided interventions, and renal complications post-cardiac interventions.

Analysis of his publications reveals expertise in randomized clinical trials (e.g., ACTIV-4, MODE Trial), multimodal time-series data in sleep studies, and biomarker discovery for conditions like COVID-19 and malignant hyperthermia. He employs advanced statistical modeling for outcomes such as ventilator-free days, vascular reactivity, and medication safety.

Shotwell’s leadership role at VBDCC highlights his commitment to bridging biostatistical innovation with clinical practice. His dual appointment reflects interdisciplinary collaboration between biostatistics and anesthesiology, advancing evidence-based approaches in perioperative care and critical illness management.