Mary Jo Pilat

Mary Jo Pilat is a Clinical Associate Professor in the Physician Assistant Studies department at Wayne State University. Her research focuses on oncology and clinical trials, particularly involving PARP inhibitors, IDH mutations, and BRCA-mutated cancers. She teaches courses in Clinical Medicine and has contributed extensively to cancer therapy research.

• Primary Research Interests: Oncology, Clinical Trials, PARP Inhibitors, IDH Mutant Tumors, BRCA Mutations, Drug Resistance

Key Trends in Publications: Dr. Pilat's recent work emphasizes precision oncology with PARP inhibitors (e.g., olaparib) in IDH-mutant and BRCA-mutated solid tumors, including gliomas, cholangiocarcinoma, and breast cancer. Earlier studies explore drug combinations (MEK/PI3K inhibitors), epigenetic therapies (vorinostat), and prostate cancer mechanisms (galectin-3, androgen resistance).