Mary Gray

Mary Gray, MD, is a Professor in the Department of Medicine at the University of California, San Francisco (UCSF), School of Medicine. She serves as Medical Director for Cardiology Clinical Services at Zuckerberg San Francisco General Hospital (ZSFG) and holds leadership roles including Chair of the ZSFG Medication Error Reduction Plan Committee and Associate Medical Director for ZSFG Risk Management. Her clinical responsibilities span inpatient cardiology, echocardiography, cardiac device management, anticoagulation, and eConsult services.

• Stanford University – B.A.S. in Biology and English
• UC San Diego School of Medicine – M.D.
• UC San Diego – Medicine Resident and Chief Resident
• UCSF – Postdoctoral Research Fellow and Clinical Cardiology Fellow

Dr. Gray’s research centers on the molecular mechanisms of cardioprotection, particularly in the context of ischemia-reperfusion injury, heart failure, and the paradoxical protective effects of moderate alcohol consumption. Her work investigates signaling pathways involving protein kinase C epsilon (PKC-ε), sphingosine-1-phosphate receptors, mitochondrial function, and oxidative stress. She has explored how ethanol and cigarette smoke influence cardiac injury and protection, with implications for preventive and therapeutic strategies.

Her selected publications reveal a strong focus on experimental cardiology using animal models, with recurring themes in mitochondrial dysfunction, kinase signaling, and cardioprotective pharmacology. The research spans biochemistry, physiology, and translational cardiology, often published in high-impact journals such as the American Journal of Physiology and Journal of Biological Chemistry.

Dr. Gray has been a Principal Investigator on multiple NIH-funded grants, including R01 and R21 awards, demonstrating sustained research productivity and scientific leadership. Her work has contributed to understanding how metabolic and signaling pathways can be harnessed to protect the heart from injury.

She has no listed scientific awards in the provided text, but her publications are widely cited and have influenced research in cardioprotection and mitochondrial biology. She collaborates with key researchers at UCSF, including Gary Cecchini, Xiaokui Ma, and Raymond Swanson.

Dr. Gray does not have any listed advisees or students in the provided information. She is not described as part-time, retired, or former staff, indicating active engagement in her academic and clinical roles. She is involved in clinical operations, research funding, and hospital administration, reflecting a multifaceted academic career.