Martin Kampmann

Martin Kampmann is a Professor at the University of California San Francisco (UCSF), where he leads a research lab focused on aging-associated neurodegenerative diseases, particularly Alzheimer's disease and frontotemporal dementia (FTD). His work integrates CRISPR-based functional genomics, human iPSC-derived neurons and glia, and 3D assembloid models to investigate mechanisms of protein aggregation, neuronal vulnerability, and glial contributions to disease pathology.

• Major research themes include tau proteostasis, neuron-glia interactions, and endosomal trafficking in Alzheimer's disease
• Key methodologies: arrayed CRISPR screening, in vivo AAV-episome sequencing, and iPSC-derived cell models

His lab has pioneered scalable CRISPR platforms for dissecting disease mechanisms at single-cell resolution. Current projects examine genetic modifiers of tau toxicity, microglial roles in synaptic pruning, and astrocyte reactivity in neuroinflammation.

Scientific awards include:

• Chan Zuckerberg Biohub Investigator (2017)
• NIH New Innovator Award (2015)
• Allen Distinguished Investigator Award (2015)
• NIH Pathway to Independence Award (2014)