Martin Högbom

Martin Högbom is a Professor of Biochemistry at the Department of Biochemistry and Biophysics, Stockholm University. His research focuses on understanding how protein structure relates to function, particularly in proteins utilizing redox-active metal cofactors or radicals for catalysis.

• Host institution: Stockholm University
• Research areas: Metalloenzymes, Redox chemistry, Enzyme catalysis, Mycobacterial respiratory systems, Bioimetic catalysts

His group employs advanced techniques such as synchrotron X-ray crystallography, free-electron laser crystallography, Cryo-EM, and protein design to investigate challenging chemical reactions in biological systems. Key projects include:

• Structural analysis of high-valent metal sites in proteins
• Elucidating Mycobacterial respiratory system architecture
• Developing bioimetic catalysts for green chemistry
• Exploring radical-containing protein structures

Recent articles highlight his work on:

• Drug inhibition mechanisms in tuberculosis
• Charge transfer dynamics in respiratory supercomplexes
• Metal cofactor characterization using electron diffraction
• Structural insights into antibiotic resistance proteins

His research has implications for both medical and environmental applications, including potential new antibiotic targets and sustainable industrial catalysts.