Britt-Marie Sjöberg

Professor Britt-Marie Sjöberg at the Department of Biochemistry and Biophysics, Stockholm University, leads pioneering research on ribonucleotide reductase (RNR) systems. Her work spans structural biology, enzymology, and antibiotic development targeting pathogenic microorganisms.

• Focus on RNR's evolutionary origins
• Structural characterization of NrdR repressor
• Development of novel antimicrobial agents

Recent studies explore ATP-cone regulation, metal-free radical generation, and thermostable enzyme mechanisms. Her group's publications in leading journals like Science and Nature reveal critical insights into RNR's role as a DNA synthesis catalyst and therapeutic target.

Key collaborations involve structural analysis with Frontiers in Molecular Biosciences and Journal of Biological Chemistry studies on Mn(IV,III) cofactors and semiquinone maturation. Current projects aim to translate RNR understanding into clinical antibiotic applications.