معرفی
Markus Delling is an Associate Professor of Physiology at the University of California, San Francisco (UCSF) School of Medicine, where he leads the Delling Lab. His research primarily focuses on the molecular mechanisms of primary cilia, calcium signaling, and ion channel function in cellular physiology and disease processes.
Dr. Delling's research interests center on the role of primary cilia as specialized signaling organelles, particularly investigating polycystin channels and their involvement in calcium signaling pathways. His work has significant implications for understanding polycystic kidney disease (ADPKD) and other ciliopathies.
- Primary cilia structure and function
- Polycystin channel regulation
- Calcium signaling mechanisms
- Ion channel physiology
- Ciliary signaling in development and disease
His publication record shows consistent contributions to the field of ciliary biology and ion channel research, with a clear trajectory toward understanding the molecular basis of polycystin channel function and its implications for therapeutic development in polycystic kidney disease. Recent work has increasingly focused on lipid regulation of ciliary channels and the development of novel therapeutic approaches.
Dr. Delling currently serves as Principal Investigator on multiple NIH-funded research projects, including:
- A comprehensive map of polycystin channel regulation and its implications in polycystic kidney disease (R01DK127277, 2021-2025)
- Polycystin activators as novel therapeutic approach for ADPKD (R21DK129906, 2021-2023)
- Regulation and functional characterization of ciliary calcium signaling (R01GM130908, 2019-2023)
His research group, the Delling Lab, collaborates extensively with other leading researchers in the field including Jeremy Reiter, Gabriel Loeb, and David Raleigh. The lab employs a multidisciplinary approach combining electrophysiology, molecular biology, and advanced imaging techniques to investigate ciliary signaling mechanisms.
