Mark J Osborn

Mark J Osborn is an Associate Professor at the University of Minnesota, affiliated with the Pediatric Blood & Marrow Transplant & Cellular Therapy division and the Center for Genome Engineering. His research focuses on advancing genome editing and cellular therapies for genetic and hematologic diseases.

Research Interests: Dr. Osborn's work centers on genome editing technologies such as CRISPR, base editing, and prime editing, with applications in epidermolysis bullosa, Fanconi anemia, sickle cell disease, and graft-versus-host disease. He develops novel delivery systems and therapeutic strategies for in vivo and ex vivo gene correction.

Publications and Research Trends: His recent publications highlight innovations in prime editing for large gene integration, CRISPR-associated transposases, and biosensing platforms. The work spans translational applications in dermatology, hematology, and diagnostics, often involving collaborations with leading institutions like the Broad Institute and NIH.

Scientific Awards:

• No specific awards listed in the provided text.

Grants and Advising: Dr. Osborn is a Principal Investigator on multiple active grants from the NIH, Department of Defense, and Bill & Melinda Gates Foundation, including projects on wastewater surveillance, HIV/SCD cures, and erythrocyte-based resuscitation fluids. While no students are listed, his role as PI and collaborator indicates mentorship and team leadership.

Labs and Teams: He is part of the Center for Genome Engineering and collaborates closely with researchers such as Jakub Tolar and Brian Blazar, contributing to multidisciplinary teams focused on cellular and gene therapies.