Mark Hart

Mark Hart is a Research Microbiologist at the Division of Microbiology (HFT-250), National Center for Toxicological Research, U.S. Food and Drug Administration. He is affiliated with the University of Arkansas for Medical Sciences (UAMS) College of Medicine, Department of Microbiology and Immunology.

Research Focus:

• Staphylococcus aureus pathogenesis and antibiotic resistance
• Regulation of extracellular virulence factors via agr and sarA systems
• Development of passive immunotherapy alternatives to antibiotics
• Host-pathogen interactions in staphylococcal pneumonia and surgical site infections
• Probiotic approaches using Lactobacillus for infection prevention
• Proteomic profiling of S. aureus strains

Publications Trends: His work spans proteomic analysis of virulence factors, regulatory system impacts on pathogenesis, and bioengineered probiotic applications. Research emphasizes combating hospital-acquired infections through mechanistic understanding and therapeutic innovation.

Technical Expertise: Utilizes SDS-PAGE, nano LC/MS/MS for protein quantitation, and genomic analysis to study microbial pathogenesis.