معرفی
Dr. Mark Graham is a Senior Lecturer at the Faculty of Medicine and Health, University of Sydney, and serves as Group Leader at the Children’s Medical Research Institute. His research focuses on the molecular mechanisms of synaptic transmission and neurological diseases, bridging biochemical pathways with therapeutic discovery.
- Education: Honours in Medical Science (Westmead), PhD (Children’s Medical Research Institute)
Research Interests: Dr. Graham investigates phosphorylation-based cellular signaling to identify pathways and biomarkers in synaptic transmission and diseases like epilepsy, autism, and schizophrenia. His group employs mass spectrometry, biochemical assays, and functional studies to map regulatory mechanisms.
Article Trends: Recent work spans proteostasis in Tau immunotherapy, ketogenic diet effects in Kabuki syndrome, dysferlinopathy prevention via gene expression, and synaptic condensate formation in neurodegeneration. These studies integrate proteomics, neurogenetics, and synaptic biology.
Grants: His projects have been supported by NHMRC, MRFF, ARC, and institutional grants, including RTTomics for Rett syndrome and ALPK1 dysfunction in retinal diseases.
Labs & Collaborations: The Synapse Proteomics group collaborates with institutions like the University of Sydney Brain and Mind Centre, leveraging cortical organoids, mouse models, and phosphoproteomics for interdisciplinary discoveries.