معرفی
Marielle Boonen is a dedicated researcher at the University of Namur, affiliated with the Namur Research Institute for Life Sciences (URPHYM). Her work is deeply rooted in lysosomal biology, intracellular protein trafficking, and molecular cell biology, contributing significantly to understanding lysosomal function and dysfunction. She holds a Doctor of Science degree and has led and participated in multiple long-term research projects since 2003, often in principal investigator or co-investigator roles.
- Doctor of Science, University of Namur, 2007
- Master in Biology, University of Namur, 2003
Her research focuses on the molecular mechanisms governing lysosomal protein sorting, with special emphasis on mannose-6-phosphate independent pathways, lysosomal membrane proteins like p40, and the role of hyaluronidases. She investigates how defects in these systems contribute to diseases such as lysosomal storage disorders and metabolic conditions. Her work bridges fundamental cell biology with potential clinical implications.
Recent publications (2023–2025) reveal a strong trend in studying signaling pathways (e.g., IGF1R) that modulate cell survival in lysosomal dysfunction, lysosomal transporters (SLC35F family), and lipid-induced renal injury. These studies employ advanced cell and molecular biology techniques, often using knockout models and disease-relevant cell lines.
She has contributed to scientific discourse through participation in key conferences such as the 4th International Conference on Glycoproteinoses (2015) and organized events like 'The fascinating world of lysosomes' (2024), highlighting her active role in the academic community.
Marielle Boonen has supervised graduate students, including PhD and Master’s candidates, guiding research on lysosomal pathways and cell death resistance. While no specific grants are detailed beyond project listings, her sustained funding since 2003 indicates successful grant acquisition. She collaborates extensively with experts like Michel Jadot and Bernard Flamion.
She is involved in a dynamic research environment within URPHYM, contributing to a multidisciplinary team focused on lysosomal function, intracellular trafficking, and related pathologies. Her lab's fingerprint highlights strong expertise in proteins, lysosomes, receptors, sorting mechanisms, and hydrolases.
