Marie Carlén

Marie Carlén is a Professor of Neuronal Networks at the Department of Neuroscience, Karolinska Institutet, where she leads the Neural Circuits of Cognition research group. Her work focuses on the prefrontal cortex (PFC), a brain region central to cognitive functions such as attention, decision-making, working memory, and goal-directed behavior. She employs cutting-edge techniques including optogenetics, large-scale electrophysiology, calcium imaging, and circuit tracing in rodent models to unravel the cellular and circuit mechanisms underlying cognition and their disruption in psychiatric disorders.

Her academic journey began with a Ph.D. in medicine from Karolinska Institutet in 2005, followed by postdoctoral training at MIT’s Picower Institute under Professor Li-Huei Tsai. She returned to Karolinska Institutet in 2010 and was promoted to full Professor in 2022. She is also a Docent (2017) and has held prestigious fellowships including ERC Starting Grant and Wallenberg Scholar (2019, 2024).

Marie Carlén's research spans systems and cellular neuroscience, with a strong emphasis on inhibitory interneurons (especially parvalbumin-expressing cells), neural oscillations, and PFC-striatum interactions. Her recent publications reveal a consistent focus on decoding prefrontal circuit dynamics, the role of specific neuron types in cognition, and comparative brain architecture. She collaborates extensively with her partner, Konstantinos Meletis, also a KI researcher.

She has been recognized with numerous scientific honors:

• Member, Nobel Assembly at Karolinska Institutet (2025–)
• Member, The Royal Swedish Academy of Sciences (2024–)
• Wallenberg Scholar (2024, 2019)
• ERC Starting Grant (2013)
• Wallenberg Academy Fellow (2012)
• NARSAD Young Investigator Awards (2010, 2008)

She actively mentors students and researchers, with open applications welcomed to her lab. Her work is supported by major grants, including from the Knut and Alice Wallenberg Foundation, enabling high-risk, high-reward research in brain function and disease.

Her lab investigates the functional definition of the prefrontal cortex across species, develops novel tools for neural recording, and explores circuit imbalances in conditions like autism and schizophrenia. She is a strong advocate for ethical animal research and promotes gender equality in science.