Marianna Nalli

Marianna Nalli is an Associate Professor in the Department of Pharmaceutical Chemistry and Technology at Sapienza University of Rome. She teaches Analysis of Medicines II with Laboratory for Pharmacy students and Phytotherapeutic Chemistry for Applied Pharmaceutical Sciences, delivering courses in blended mode with mandatory and optional attendance requirements respectively.

Her research spans medicinal chemistry with emphases on anticancer drug discovery (particularly tubulin and β-catenin inhibitors), antiviral development (SARS-CoV-2, norovirus), and molecular targeting strategies. She integrates computational modeling with biological validation to design dual-targeting agents against multidrug-resistant cancers and viral pathogens, frequently focusing on sulfonamide-based compounds and pyrrole derivatives.

Recent publications (2020-2024) reveal consistent innovation in Wnt/β-catenin pathway modulation, tubulin assembly inhibition, and structure-based antiviral design. Her work demonstrates strong translational potential through in vivo cancer models and resistance profiling, with significant contributions to carbonic anhydrase inhibitors and PDZ domain modulators.

Dr. Nalli leads two major research projects: Brain-penetrant microtubule-targeting agents and New 3-Aroyl-1-arylpyrroles (ARAPs) as anticancer drugs through an interaction at Colchicine site of Tubulin. While formal advisee lists aren't provided, her projects inherently involve mentoring graduate researchers in drug discovery pipelines spanning computational design to preclinical validation.