معرفی
Margarida M. Barroso is a Professor in the Department of Molecular and Cellular Physiology at Albany Medical College. Her research focuses on accelerating pre-clinical drug discovery through novel imaging assays for targeted anti-cancer drug delivery, with expertise in Forster Resonance Energy Transfer (FRET) and fluorescence lifetime imaging (FLIM). She investigates membrane trafficking pathways, receptor-mediated transport, and endosome-mitochondria interactions in live cancer cells.
Research Highlights:
- Developed non-invasive whole-body FLIM-FRET imaging to visualize receptor engagement in tumor xenografts
- Studies iron-mediated organelle interactions in cancer metastasis
- Pioneered quantitative lifetime-based imaging for drug target engagement and pharmacokinetics
Education:
- PhD, University of Lisbon (1991)
- Postdoctoral Research, University of Lisbon
- BS, University of Lisbon (1986)
- Princeton University
Methodologies:
- FLIM-FRET Imaging
- Time-Gated SPAD Cameras
- Phasor Analysis
- Quantitative Bioluminescence
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