Margarida C. C. Braga

Margarida C. C. Braga serves as Assistant Professor with permanent appointment at the Faculty of Science and Technology, New University of Lisbon (FCT/UNL), Portugal, where she conducts research on neurodegenerative disease mechanisms.

Her core research interests include:

• Cellular and molecular mechanisms of MPTP/MPP+-induced neurodegeneration in Parkinson's disease models
• Role of JNK protein kinase in neurodegenerative pathways
• Neuroprotective function of glutathione S-transferase and its modulation of JNK activity
• Therapeutic potential of tauroursodeoxycholic acid against MPTP/MPP+ toxicity

Analysis of her 2009-2012 publications reveals consistent investigation of molecular pathways in Parkinson's disease, particularly JNK signaling cascades and phase II detoxification enzymes. Her work demonstrates how glutathione S-transferase regulates neurotoxicity and identifies tauroursodeoxycholic acid as a promising neuroprotectant, primarily using in vivo mouse models and in vitro neuroblastoma systems to bridge molecular mechanisms with potential therapeutic strategies.