معرفی
Prof. Dr. Marek Basler is an Associate Professor of Infection Biology at the Biozentrum, University of Basel, leading a research group focused on the Type VI Secretion System (T6SS) in bacterial pathogens. His work bridges structural biology, molecular microbiology, and computational analysis to unravel the mechanisms of this contractile nanomachine.
- PhD in Microbiology (2007, Institute of Microbiology, CAS, Prague)
- Postdoctoral Fellow (2007–2013, Harvard Medical School)
- Assistant Professor (2013–2018) and Associate Professor (since 2018) at Biozentrum
His research explores the structure, assembly, and therapeutic potential of the T6SS, a critical virulence factor in pathogens like Pseudomonas aeruginosa. Key themes include bacterial defense strategies, intermicrobial competition, and host-pathogen interactions. Recent projects highlight T6SS roles in antibiotic resistance and horizontal gene transfer.
The most recent publications (2025–2024) reveal novel insights into T6SS activation by environmental stress, toxin diversity, and host cell targeting. Trends span microbial ecology, nanomachine dynamics, and computational modeling of bacterial interactions.
Scientific Awards:
- EMBO Membership (2023)
- ERC Consolidator Grant (2019)
- EMBO Gold Medal (2018)
- Friedrich Miescher Award (2018)
- EMBO Young Investigator (2015)
His lab (Basler Lab) utilizes state-of-the-art microscopy, biochemical techniques, and live-cell simulations (e.g., BacFighT6). Collaborations span institutions like Harvard Medical School and NCCR-AntiResist, with future work targeting antibacterial therapies.
