Marcelo Pablo Coba

Marcelo Pablo Coba, PhD, is an Associate Professor in the Department of Psychiatry and the Behavioral Sciences at the University of Southern California. His research employs systems biology to investigate neurodevelopmental and neurodegenerative disorders, focusing on synaptic protein networks and signaling pathways. He integrates proteomics, CRISPR, hiPSC-derived models, and computational approaches to dissect mechanisms underlying schizophrenia, autism, and Alzheimer's disease.

Research Interests: Dr. Coba's work centers on:

• Synaptic plasticity and post-synaptic density complexes
• Functional genomics of neurodevelopmental disorders
• Multi-omics profiling of synaptic dysfunction
• Protein interaction networks in psychiatric diseases
• hiPSC and organoid models of brain disorders

His recent publications (2017–2025) emphasize synaptic biology, neurogenomics, and the development of experimental models. A consistent theme is the integration of proteomic data with genetic and functional analyses to map disease pathways in disorders like schizophrenia and autism. Key methodological advances include organoid technology, phosphoproteomics, and CRISPR-based functional screens.

Dr. Coba leads a laboratory specializing in proteomic assays, mouse genetics, and hiPSC technology. The team focuses on defining spatiotemporal protein networks to stratify brain disorders by molecular signatures and genotype-phenotype relationships.