معرفی
Marcello DiStasio is an Assistant Professor in the Departments of Pathology and Ophthalmology at Yale School of Medicine. He is also Co-director of the Yale Legacy Tissue Donation Program. His research focuses on neuroimmunology, computational pathology, and integrating spatial omics technologies with traditional histopathology to study diseases of the central nervous system, including neurodegeneration, cancer, and immune dysregulation.
Education: MD and PhD from SUNY Health Science Center at Brooklyn, with biomedical engineering training from NYU Polytechnic. Residency and fellowship training at Harvard Medical School-affiliated institutions.
Research Interests: DiStasio develops machine learning algorithms to analyze histologic and genomic data, aiming to classify tumors and understand pathologic processes in the brain, retina, spinal cord, and peripheral nervous system. Key areas include spatial omics applications, neuro-oncology, and inflammatory mechanisms in diseases like macular degeneration and inclusion body myositis.
Publications: Over 30 peer-reviewed articles focus on spatial biology, single-cell profiling, and computational pathology. Recent work explores tumor microenvironment interactions, immunoprofiling in neuromuscular disorders, and epigenetic states in spermatogenesis. Methodological contributions include tools for aligning spatial omics data with histologic annotations.
Labs & Teams: Leads the DiStasio Lab, which bridges computational methods with clinical pathology. Collaborates with the Hafler Lab and Wu Tsai Institute on interdisciplinary projects. Active in the Janeway Society for physician-scientists.
