معرفی
Marc B. Cox is Professor and Department Chair of Pharmaceutical Sciences at the University of Texas at El Paso (UTEP), with primary appointment in the Border Biomedical Research Center (BBRC). His molecular endocrinology research focuses on steroid hormone receptor signaling pathways and chaperone protein regulation in diseases like prostate cancer.
Dr. Cox's laboratory investigates how immunophilins (particularly FKBP51/FKBP52) regulate steroid hormone receptors through receptor folding, hormone binding, and nuclear translocation mechanisms. His team develops selective FKBP inhibitors for hormone-related cancers using yeast genetics for high-throughput drug screening and studies molecular chaperone-mediated stress responses across cancer and neurodegenerative diseases. Current work emphasizes therapeutic targeting of FKBP52 in castration-resistant prostate cancer.
Analysis of recent publications shows concentrated research on FKBP52-targeted therapeutics for prostate/breast cancer, with growing emphasis on translational applications and collaborative initiatives addressing Mexican-American cancer disparities. His work bridges basic molecular mechanisms to drug development pipelines.
Scientific Awards:
- Senior Member, National Academy of Inventors
- State Bar of Texas Inventor of the Year (2016)
Dr. Cox mentors graduate students through UTEP's Community of Engaged Scholars and Entrepreneurship Community of Practice. His major grants include $6.1M for cancer detection, $19M for Mexican-American cancer research, $15.2M NIH biomedical training funding, and TTUHSC El Paso seed grants. These support BUILDing SCHOLARS diversity initiatives and Innovation and Commercialization Fund projects.
His laboratory in UTEP's Bioscience Research Building operates within the Border Biomedical Research Center, collaborating with TTUHSC El Paso on prostate cancer treatment research and commercialization efforts using yeast-based screening platforms and stress response reagents.
