Manuel Scimeca

Manuel Scimeca is a Professor at the University of Rome Tor Vergata's School of Medicine, specializing in environmental pollution's impact on human pathology. His research decodes complex relationships between toxic exposures and disease pathogenesis using advanced microscopy techniques.

His primary investigations examine toxic metal bioaccumulation in cancers, particularly aluminum's role in promoting epithelial-mesenchymal transition in colorectal and breast cancers. Secondary research explores microcalcification dynamics in breast cancer and atherosclerosis pathogenesis.

Scimeca's work employs transmission electron microscopy with EDX microanalysis to detect nanoscale metal deposits in human tissues. Recent findings demonstrate aluminum accumulation correlates with increased tumor mutational burden and expression of EMT biomarkers. His team's multi-omics approach integrates histopathology with next-generation sequencing to identify pollution-related genomic instability patterns.

He co-founded university spin-offs TMALab and ORCHIDEALab to translate diagnostic and therapeutic innovations. Current projects investigate pollution's contribution to carotid plaque instability and develop targeted therapies leveraging mineralization biomarkers.