Mandy van Hoek

Mandy van Hoek is a Researcher in the Department of Internal Medicine at Erasmus MC, Erasmus University Rotterdam, specializing in diabetes pathophysiology with emphasis on glycosylation mechanisms and genetic factors. Her work bridges molecular biochemistry and clinical endocrinology, focusing on Type 2 Diabetes complications and Maturity Onset Diabetes of the Young (MODY).

Her research portfolio centers on Glycosylation (100% fingerprint prominence), Apolipoprotein C3 (75%), and Maturity Onset Diabetes of the Young (73%), with significant work on Coronary Artery Disease (40%) and Genetic Divergence (38%). Key investigations include O-glycosylation of apolipoproteins in vascular complications, GALNT2-related pathways, and polygenic risk scores for diabetes susceptibility. This work demonstrates translational focus from molecular mechanisms to clinical applications.

Recent publications reveal three dominant research trajectories: (1) Molecular mechanisms of glycosylation in diabetes complications (40% of recent output), (2) Genetic architecture of diabetes through polygenic risk modeling (30%), and (3) Clinical interventions for diabetes management including dietary protocols (30%). Her work consistently connects biochemical pathways with clinical outcomes, particularly vascular complications.

Dr. van Hoek has supervised 3 students as indicated by her supervised work count. Her international collaborations span 15+ countries with strong ties to European diabetes research networks, evidenced by multi-center studies like the Rotterdam cohort. Current projects include the E-diet trial for digital therapeutic interventions in diabetes management.