Mandeep Mehra

Mandeep Mehra, MD, MSc is the William Harvey Distinguished Chair in Advanced Cardiovascular Medicine and Professor of Medicine at Harvard Medical School. He concurrently serves as Executive Director of the Center for Advanced Heart Disease at Brigham and Women’s Hospital in Boston, Massachusetts, and previously acted as founding Medical Director of the Heart and Vascular Center (2013–2019).

Education & Leadership Credentials

• Certificate in Executive Leadership — Harvard Business School
• Master of Science in Health Economics and Management (2018) — London School of Economics, as a “Braunwald Scholar”

Research Focus
Dr. Mehra’s investigative portfolio centers on the entire spectrum of advanced heart failure and cardiac transplantation. Key areas include:

• Natural history & mechanistic underpinnings of cardiac allograft vasculopathy
• Development and validation of genomic biomarkers for non-invasive detection of transplant rejection
• Design and clinical evaluation of next-generation, fully magnetically levitated left-ventricular assist devices (HeartMate 3)
• Discovery of the obesity paradox in chronic heart failure
• Establishment of international guidelines for patient selection and post-transplant care

Publication Trends
Across his 500+ peer-reviewed articles, a clear evolution is evident: from foundational transplant immunology and vasculopathy studies (2000–2010) to large-scale, practice-changing randomized trials of LVAD therapy and antithrombotic regimens (2015–2025). Recent work leverages big-data analytics, machine-learning phenotyping, and digital health sensors to refine risk prediction and personalize therapy.

Scientific Awards & Honors

• William Harvey Distinguished Chair in Advanced Cardiovascular Medicine
• President, International Society of Heart and Lung Transplantation (2008)
• President, Heart Failure Society of America
• Ranked #1 journal in category (as Editor-in-Chief, Journal of Heart and Lung Transplantation, 2010–2020)
• Braunwald Scholar, London School of Economics

Leadership & Mentorship
Dr. Mehra directs multi-institutional consortiums such as the MOMENTUM 3 and ARIES-HM3 trials, mentoring emerging clinician-scientists in cardiovascular medicine and health-economics research. Grant funding derives from NHLBI, industry partnerships, and international collaborative networks.

Laboratory & Clinical Teams
He oversees the Center for Advanced Heart Disease at Brigham and Women’s Hospital, integrating bench-to-bedside translational programs, advanced imaging core labs, and a dedicated clinical research unit focused on mechanical circulatory support and transplant outcomes.