Malcolm Clench

Malcolm Clench is Professor of Mass Spectrometry in the Department of Biosciences and Chemistry at Sheffield Hallam University, where he has been a key figure since 2007. His work bridges analytical chemistry, biomedical research, and forensic science through advanced mass spectrometry imaging techniques.

• BSc(Hons) Applied Chemistry, Sheffield City Polytechnic (1977–1981)
• PhD in Peptide and Protein Sequencing by Fast Atom Bombardment Mass Spectrometry, Manchester Polytechnic/UMIST (1982–1985)

His research focuses on the development and application of mass spectrometry imaging (MSI), particularly MALDI-MSI, for spatially resolved molecular analysis in diverse contexts. Key areas include biomedical imaging (cancer, brain lipids, drug distribution), forensic science (fingermark analysis, condom detection, blood identification), and plant biochemistry (herbicide translocation, nitrogen cycling). He also investigates pharmacokinetics and toxicology, using MSI to study drug metabolism and tissue responses.

The recent publications highlight a strong trend toward clinical translation of MSI, with applications in malignant mesothelioma, lung imaging, and skin models. Innovations in sample preparation, ionization methods, and multimodal imaging demonstrate technical leadership. His work frequently involves collaborative, interdisciplinary teams and addresses both fundamental biochemical questions and practical diagnostic or forensic challenges.

While no formal awards are listed, his sustained high-impact output in journals like Analytical Chemistry and PNAS indicates significant recognition in the field.

Malcolm Clench has mentored or collaborated extensively with researchers such as Laura M. Cole, Simona Francese, and Sarah L. Haywood-Small. He has contributed to major projects in drug development, cancer research, and forensic methodology. His peer review activities for journals like Analytical Chemistry and Journal of the American Society for Mass Spectrometry reflect his role as a scientific gatekeeper.

He leads or contributes to a dynamic research environment focused on pushing the boundaries of mass spectrometry imaging in both clinical and non-clinical settings, with ongoing work in 3D imaging, quantitative analysis, and novel matrix applications.