معرفی
Maria Cristina Limon Mortes is a Professor in the Department of Microbiology at the Faculty of Biology, University of Seville, where she teaches Microbiology I and Biochemistry and Industrial Microbiology courses. Her academic profile combines active research leadership with undergraduate instruction in core microbiology disciplines.
Her research centers on signal transduction mechanisms in mammalian cells, with particular emphasis on ubiquitin-mediated protein degradation pathways. Key focus areas include E3 ubiquitin ligase regulation (especially SCF complexes), cell cycle control through securin and PLK1, and DNA damage response mechanisms with direct implications for cancer biology and chemotherapy resistance. This work bridges fundamental molecular processes with therapeutic applications in oncology.
Professor Limon Mortes leads the Signal Transmission in Mammalian Cells Research Group and maintains continuous research funding through competitive Spanish national projects including:
- Papel de la ubiquitín ligasa SCF en la resistencia a las quimioterapias basadas en platino (PID2020-118774RB-C21)
- Transmisión de señal en células de mamífero (2021/BIO-211)
- La desregulación de la estabilidad de las proteínas como mecanismo de sensibilización a quimioterapias (SAF2017-87358-C2-1-R)
Her publication record from 2006-2023 reveals consistent contributions to understanding protein degradation mechanisms in cell cycle regulation. Recent work (2019-2023) demonstrates how SCF(FBXW7) regulates p53 recovery after DNA damage and how cisplatin induces autophagy-mediated degradation of DNA repair complexes. These studies show increasing focus on translational cancer research while maintaining strong mechanistic foundations in ubiquitin biology.
Professor Limon Mortes has secured continuous research funding through Spain's National Research Plan competitions, with current projects addressing critical gaps in understanding chemotherapy resistance mechanisms. Her group's work on platinum-based therapy resistance provides potential targets for improving cancer treatment efficacy, particularly through modulation of ubiquitin ligase activities.
The Signal Transmission in Mammalian Cells Research Group employs advanced molecular and cellular techniques to investigate protein stability networks, with particular expertise in ubiquitin-proteasome system analysis and DNA damage response pathways. This work positions the group at the intersection of basic cell biology and translational cancer research.
