Lukasz Ciszewski

Lukasz Ciszewski is a Researcher at the Centre of Gene and Cell Therapy, focusing on developing antisense oligonucleotide therapies for genetic disorders. His work spans neurofibromatosis type I (NF1) and facioscapulohumeral muscular dystrophy (FSHD), with a particular emphasis on molecular mechanisms involving G-quadruplex structures and mRNA regulation. He holds a Doctoral Thesis from 2018 on nucleic acid structures influencing DUX4 expression in FSHD.

Research Interests:

• Design of antisense therapies targeting genetic mutations
• Mechanisms of mRNA processing and exon skipping
• Role of G-quadruplex ligands in gene expression regulation
• Development of personalized medicine approaches for rare genetic disorders

Key Projects:

• Principal contributor to a Rosetrees Trust-funded project (2014-2018) developing antisense oligonucleotide drugs for FSHD
• Collaborative work on NF1 therapeutic strategies through exon skipping and antisense morpholino treatments

Labs & Teams:
Involved in multidisciplinary teams focusing on gene therapy and nucleic acid-based drug development at the Centre of Gene and Cell Therapy.