Lucy Glover

Lucy Glover is a Researcher and Group Leader of the Trypanosome Molecular Biology laboratory at the Department of Parasites and Insect Vectors, Institut Pasteur, Paris, France. She joined the institute in March 2016 as a G5 group leader, focusing on the molecular mechanisms of antigenic variation and DNA repair in Trypanosoma brucei, the causative agent of Human African Trypanosomiasis. Her research integrates molecular, biochemical, and high-throughput approaches to study DNA recombination and immune evasion.

• Institut Pasteur, Paris (2016–Present)
• PhD, London School of Hygiene and Tropical Medicine

Her research interests center on antigenic variation, DNA repair, and homologous recombination in trypanosomes. She investigates how DNA double-strand breaks influence variant surface glycoprotein (VSG) switching, a critical process for parasite survival in the host. Her lab uses advanced techniques such as RIT-seq, phosphoproteomics, and CRISPR-based tools to dissect these mechanisms at the molecular level.

The recent publications of Lucy Glover span molecular parasitology, DNA damage response, and diagnostic development. Key themes include the role of the MRN complex in DNA repair, phosphoproteomic profiling of DNA damage responses, and the design of CRISPR-based diagnostics for HAT. Her work reveals how chromosomal context influences repair pathways and antigenic variation, contributing to a deeper understanding of parasite biology.

While no formal scientific awards are listed in the provided text, her contributions are evident through high-impact publications and leadership in collaborative research projects.

Lucy Glover advises several PhD and postdoctoral researchers, including Emilia MacLaughlin, Nuria Sima Teruel, and Alix Thivolle. Her lab is supported by institutional initiatives such as LabEx IBEID and transversal drug discovery programs. She collaborates with teams working on host-pathogen interactions, genomics, and infectious disease epidemiology.

Her laboratory is part of the Department of Parasites and Insect Vectors and participates in departmental retreats and seminars. The team includes post-docs, research engineers, and administrative staff, reflecting a collaborative and interdisciplinary research environment focused on combating neglected tropical diseases.