Lucas Pozzo-Miller

Lucas Pozzo-Miller is a Professor at Michigan State University, affiliated with the Neuroscience Program, BioMolecular Science Gateway, Cell & Molecular Biology Program, and Genetics & Genome Sciences Program. His research centers on neurodevelopmental disorders, synaptic plasticity, and molecular neuroscience, with a specialized focus on Rett syndrome pathophysiology and therapeutic interventions.

Research interests span multiple domains:

• Neurodevelopmental Disorders: Mechanisms of Rett syndrome (MECP2 dysfunction), autism spectrum disorders, and dendritic spine pathologies.
• Synaptic Plasticity: BDNF/TrkB signaling, glutamate receptor trafficking, and structural remodeling of dendritic spines in learning/memory contexts.
• Molecular Neuroscience: Epigenetic regulation, ion channel dynamics (e.g., TRPC, ASIC1a), and kinase signaling pathways (PKA, ERK) in neuronal function.

His recent publications (2020-2025) predominantly investigate Rett syndrome models, emphasizing: (1) MeCP2 gene rescue strategies, (2) dendritic spine restoration via TrkB ligands, (3) hippocampal/cortical circuit dysfunction, and (4) novel therapeutic targets. No awards, grants, or student advisees are documented in available sources.