معرفی
Lucas Pozzo-Miller is a Professor in the Department of Neurobiology at the University of Alabama at Birmingham (UAB), with additional affiliations in Cell, Developmental and Integrative Biology; Psychology; and Neurology. His research focuses on neurodevelopmental disorders, particularly Rett syndrome, autism spectrum disorders, and Alzheimer's disease, examining synaptic plasticity, neuronal circuitry, and molecular mechanisms.
- 1986-1989: Biology PhD from Universidad Nacional de Córdoba, Argentina
- 1990-1992: Postdoctoral training at Case Western Reserve University
- 1992-1995: Postdoctoral work at Roche Institute of Molecular Biology
- 1998-present: Faculty member at UAB
His research examines:
- Methyl-CpG-binding protein 2 (MeCP2) dysfunction in Rett syndrome
- BDNF/TrkB signaling pathways and therapeutic development
- Corticostriatal and hippocampal-prefrontal circuit abnormalities
- Perineuronal net regulation of synaptic plasticity
- Microglial activation and neuroimmune interactions
- Epigenetic mechanisms and evolutionary conservation of MBD proteins
Key publications demonstrate:
- Altered MBD protein interactions in neurodevelopment
- Deficits in social memory circuits through vHIP-mPFC projections
- Therapeutic potential of small-molecule TrkB ligands
- Dysregulation of synaptic plasticity in multiple neurodevelopmental models
Major grants include funding from:
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institute on Drug Abuse (NIDA)
- International Rett Syndrome Foundation
- Rettsyndrome.org
- National Science Foundation (NSF)
- Yale University
Teaching activities include:
- Co-chairing and mentoring multiple dissertation committees
- Instructing courses in developmental neuroscience and neuro student summer seminars
- Participating in MEDMAP peer teaching activities
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