معرفی
Lu Yi is a Principal Researcher at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet. She leads the Precision Psychiatry research group and has directed the KI Psychiatric Genomics Institute since 2023. Her work bridges large-scale genomic data and electronic health records to advance precision psychiatry.
Her research focuses on reducing heterogeneity in major depressive disorder (MDD) through genetic subtyping, with parallel interests in cardiometabolic comorbidities and trans-Nordic genomic collaborations. She employs genome-wide association studies (GWAS), polygenic risk scoring, and population register analyses to identify biological signatures of severe depression.
Dr. Yi's publications emphasize genetic architecture of psychiatric disorders (e.g., MDD, schizophrenia), biomarker discovery, and real-world clinical applications. Recent works highlight depression subtypes, cross-disorder comorbidities, and brain-cell-type-specific pathways, reflecting a translational neuroscience approach.
She received a €1.5 million European Research Council grant and leads Sweden's contributions to NIH/EU Horizon 2020 projects. Additional honors include co-chairing the 1,700+ member Psychiatric Genomics Consortium MDD working group.
She advises PhD students (e.g., Ying Xiong, Arvid Harder) and postdoctoral researchers, focusing on genetic epidemiology and treatment-resistant depression. Her team collaborates internationally via the Nordic Tryggve consortium and KI-Psychiatric Genomics Institute infrastructure.
