Loïc Guillot & Harriet Corvol

Harriet Corvol (Professor) and Loïc Guillot (Researcher) lead a team at Saint-Antoine Hospital (Sorbonne University) focusing on cystic fibrosis (CF) pathogenesis and personalized medicine. They coordinate a national cohort of 4900 CF patients.

• Primary Affiliation: Sorbonne University / Saint-Antoine Hospital
• Secondary Affiliation: INSERM (French National Institute of Health and Medical Research)

Research Themes: Modifier gene identification, RNA-targeted therapies, and epithelial-pathogen interactions with Pseudomonas aeruginosa, Aspergillus fumigatus, and SARS-CoV-2. Their work spans genetics, pulmonary medicine, and microbiology.

Recent Trends: 2015-2023 publications show progression from basic CFTR biology to clinical translation via SLC6A14 functional studies and development of non-CFTR-dependent therapeutics. Key subfields include epithelial repair, microbial pathogenesis, and pharmacogenomic modeling.

Students:

• Doctoral: Gabrielle DUPUIS
• Master's: Clara BRONES, Marina LE ROUX-NORTIER, Yaël LELLOUCHE-JACOB, Jean LOUIS, Chloe VICCHI

Key Collaborations: North-American biostatistics teams, INSERM, and Anoat Therapeutics startup for clinical translation.