معرفی
Dr. Louise Stephen is a Research Fellow at the Roslin Institute, University of Edinburgh, within the Royal (Dick) School of Veterinary Studies. Awarded a BBSRC Discovery Fellowship in 2022, she leads research on tissue mineralisation using advanced imaging techniques in bone and fish scales to investigate subcellular processes since joining the institute in 2019.
Her research centers on matrix vesicle biogenesis and its role in skeletal development and mineralisation disorders. She employs transgenic zebrafish models and cell cultures to study how tissues mineralise, with current projects focusing on vesicle composition and regulation in health and disease. This work combines correlative light electron microscopy (CLEM) and live superresolution imaging to visualize mineralisation dynamics.
Dr. Stephen's recent publications (2023-2025) demonstrate consistent output in bone biology, with key themes including matrix vesicle function, renal osteodystrophy mechanisms, and therapeutic interventions for bone loss. Her work appears in high-impact journals such as Journal of Bone and Mineral Research and Kidney International, reflecting strong interdisciplinary collaboration.
Dr. Stephen has received the following scientific recognition:
- BBSRC Discovery Fellowship (2022)
She currently supervises PhD student Charlotte Clews and hosts summer research projects. Her active funding portfolio includes:
- BBSRC Discovery Fellowship (2023-2026, £506,473) as Principal Investigator
- Roslin Institute ISP Pump-Priming Grant (2025-2026, £22,158) as Principal Investigator
Past grants include collaborations on Duchenne muscular dystrophy therapeutics and skeletal health models. Dr. Stephen leads a research team within the Functional Genetics division that utilizes state-of-the-art imaging to study mineralisation processes, providing critical insights for understanding bone disorders.
