Louisa Nelson

Louisa Nelson is a Researcher in the Division of Cancer Sciences within the Faculty of Biology, Medicine and Health at the University of Manchester. She is affiliated with the Manchester Cancer Research Centre, contributing to cancer research that aligns with UN Sustainable Development Goals related to good health and well-being.

Her research focuses on ovarian cancer, chromosome instability, and related molecular mechanisms. Key areas include SUMOylation pathways, DNA repair mechanisms, glycosidase function, and therapeutic resistance. She employs living biobanks, cancer cell models, and genomic approaches to understand disease mechanisms and identify therapeutic vulnerabilities.

Nelson's publication record shows a strong focus on ovarian cancer therapeutics, particularly examining resistance mechanisms and novel treatment approaches. Her recent work (2021-2025) demonstrates increasing sophistication in modeling therapeutic resistance, with particular attention to DNA damage response pathways, chromosome instability as a biomarker, and combination therapies targeting multiple vulnerabilities in cancer cells.

Her research has garnered significant attention, with her 2021 paper on ovarian cancer cell line stratification receiving 80 citations and 117 Mendeley readers, indicating substantial impact in the field.

Nelson collaborates extensively within the University of Manchester and with external researchers, contributing to a robust network focused on advancing ovarian cancer research and therapeutic development.