معرفی
Longhui Zeng is an Associate Research Scientist in the Department of Cell Biology at Yale School of Medicine. His research focuses on molecular mechanisms of infection diseases, immune responses, and T cell signaling. He earned a PhD in Biology from Shanghai Jiao Tong University (2018) and conducted postdoctoral training under Xiaolei Su, specializing in phase separation, CAR T cell therapy, and immune cell signaling. His work bridges structural biology, biochemical reconstitution, and translational immunotherapy. Key research areas include PLCγ1 signaling in leukemia, biomolecular condensation in T cells, and designing synthetic chimeric T cell receptors for cancer treatment.
- Education: PhD in Biology, Shanghai Jiao Tong University (2018)
- Laboratory: Su-lab (https://su-lab.streamlinehq.com)
- Award: CRI Irvington Postdoctoral Fellowship (2021)
Research highlights include elucidating Salmonella host interactions, structural basis of biofilm formation, and mechanisms of hyperactive PLCγ1 signaling in T-cell malignancies. His recent work emphasizes engineering CAR T cells with improved sensitivity and specificity for low-antigen cancers via IDR-induced condensation.
