معرفی
Longhou Fang serves as Associate Professor in the Department of Cardiothoracic Surgery at Weill Cornell Medical College, Cornell University since 2019, with research bridging Cell and Developmental Biology. His work centers on Apolipoprotein A-I Binding Protein (AIBP) mechanisms in vascular biology and lipid metabolism.
Dr. Fang earned his B.S. from Anhui University (China, 2000) and Ph.D. from Shanghai Institute of Biochemistry (China, 2007).
His research program investigates how AIBP-mediated cholesterol efflux regulates angiogenesis, hematopoiesis, and atherosclerosis through lipid raft modulation. Key contributions include establishing AIBP's role in endothelial lineage specification via epigenetic mechanisms (MECOM regulation), sexual dimorphism in metabolic control, and therapeutic applications for vascular inflammation and choroidal neovascularization. His zebrafish and mouse models have advanced understanding of dyslipidemia-induced vascular pathology.
Publication analysis reveals consistent focus on AIBP's multifaceted functions across cardiovascular, pulmonary, and ocular systems. His work demonstrates how cholesterol bioavailability influences inflammatory cascades and stem cell fate decisions, with recent emphasis on therapeutic mimicry of AIBP mechanisms for atherosclerotic disease.
No scientific awards are documented in the provided materials.
While student mentoring and grant funding are implied by his publication volume, specific advisees and funding sources remain unlisted in the available information.
Dr. Fang directs a cardiovascular research laboratory at Weill Cornell investigating molecular pathways linking lipid metabolism to vascular development and disease, with ongoing studies on AIBP's therapeutic potential.
