معرفی
Lisa Wruck is a Professor of Biostatistics & Bioinformatics at Duke University School of Medicine and a Member of the Duke Clinical Research Institute. Her work focuses on the design and analysis of pragmatic clinical trials, real-world evidence generation, and neurocognitive data, with applications in cardiovascular disease, stroke, and health disparities.
Her educational background:
- Ph.D., Harvard University, T.H. Chan School of Public Health (2004)
Dr. Wruck's research program centers on biostatistics and bioinformatics, with a strong emphasis on pragmatic clinical research and real-world evidence. She investigates the impact of social determinants of health on cognitive outcomes and cardiovascular disease, and is actively involved in data science workforce development initiatives to train the next generation of researchers. Her primary research interests include:
- Pragmatic Clinical Trials
- Real World Evidence
- Neurocognitive Data Analysis
- Data Science Workforce Development
- Cardiovascular Disease Epidemiology
- Stroke and Dementia Outcomes
Her recent publications (2024-2025) demonstrate a consistent focus on cardiovascular outcomes, stroke, and dementia, often leveraging large pragmatic trials such as ADAPTABLE. Key themes include aspirin dosing strategies, racial and gender disparities in treatment outcomes, and the application of advanced statistical methods to real-world data for regulatory decision-making.
Scientific awards: None mentioned.
Dr. Wruck has secured substantial grant funding from diverse sources including the National Institutes of Health (NIH), industry partners (Bristol-Myers/Sanofi, Baxter), and academic institutions. Notable projects include:
- The Gut Brain Parkinson's Disease Consortium (2024-2029)
- RADx-UP CDCC (2020-2025)
- ADAPTABLE trial analyses (multiple grants)
Her role as a professor involves mentoring graduate students and postdoctoral fellows in biostatistics and clinical research, though specific advisees were not listed in the provided text.
She is actively involved in the Duke Clinical Research Institute and leads coordinating centers for multi-site studies, fostering collaborative research teams across institutions.
