Keith Allen Marsolo

Keith Allen Marsolo is Professor in the Department of Population Health Sciences and Department of Biostatistics & Bioinformatics at Duke University School of Medicine, and a member of the Duke Clinical Research Institute (DCRI). His work develops infrastructure for electronic health records (EHRs) and real-world data in observational research, public health surveillance, and learning health systems.

Education:

• Ph.D. in Computer Science, The Ohio State University (2007)

Research Focus: Dr. Marsolo specializes in data quality, common data models, and data harmonization standards for multi-center research networks. His work bridges biomedical informatics and population health to enable real-world evidence generation, particularly addressing health disparities in chronic disease management and public health surveillance through EHR-derived analytics and configurable registry architectures.

Publication Trends: Recent articles (2024-2025) emphasize EHR-based cancer classification, cardiovascular outcomes in HIV patients, pragmatic trial methodologies, and public health surveillance systems. Key themes include data provenance for quality assessment, learning health system architectures, and AI-driven approaches to real-world evidence generation, with strong emphasis on underrepresented populations.

Grants: He leads/co-leads major initiatives including:

• DCRI D-COHRe Partnership for Decentralized Clinical Trials (BARDA, 2024-2029)
• PCORnet Master Data Sharing Agreement (PCORI, 2025-2028)
• NIH Health Care Systems Research Collaboratory (2017-2028)
• DOMINO anti-Obesity Medication Implementation Study (NIDDK, 2024-2028)
• Comparative Effectiveness of IBD Medications in Children (UNC, 2025-2031)

Labs & Teams: Dr. Marsolo serves as faculty advisor for the DPHS DataShare Shared Facility and leads the DCRI's Pragmatic Health Services Research (PHSR) functional group, developing data-in-once architectures for chronic care management, quality improvement, and distributed research networks.