معرفی
Lingyin Li is a Professor in the Department of Biochemistry at Stanford University School of Medicine and a core investigator at the Arc Institute. Her research focuses on the biochemical mechanisms of immunotransmitter cGAMP, with applications in cancer and autoimmunity. She holds affiliations with Stanford's Bio-X Institute, Sarafan ChEM-H Institute, and Stanford Cancer Institute.
- B.Sc. in Chemistry, University of Science and Technology of China (2003)
- Ph.D. in Chemistry, University of Wisconsin-Madison (2010)
- Postdoctoral training in Chemical Immunology, Harvard Medical School (2015)
Dr. Li's work deciphers extracellular cGAMP biology, targeting ENPP1/ENPP3 hydrolases to enhance STING-mediated anti-cancer immunity. Her lab explores Galectin-1's role in metastasis, PELI2's regulation of interferon production, and taurine metabolism's impact on obesity. She has pioneered methods to engineer VH domains for ENPP1 inhibition and characterized phage anti-CBASS proteins.
Recent research trends include:
- Therapeutic modulation of cyclic nucleotide signaling
- Extracellular immunotransmitter dynamics
- Immune checkpoint enzyme targeting
- STING pathway activation specificity
- Tumor-immune microenvironment interactions
Scientific awards include:
- NIH Pathway to Independence Award (2015-2018)
- Baxter Foundation Faculty Scholar (2017-2018)
- NIH New Innovator Award (2017-2022)
- Ono Pharma Breakthrough Science Initiative (2017-2010)
- DOD Breast Cancer Breakthrough Level II (2018-2021)
- C&En News Talented 12 (2020)
- Eli Lilly Award in Biological Chemistry (2022)
Dr. Li advises doctoral candidates and teaches graduate-level courses including Directed Reading in Biochemistry (BIOC 299), Graduate Research (BIOPHYS 300), and The Teaching of Biochemistry (BIOC 221). Her lab collaborates with immunology and cancer research teams across Stanford and the Arc Institute.
