Linghua Wang

Dr. Linghua Wang is a tenured Associate Professor in the Department of Genomic Medicine at The University of Texas MD Anderson Cancer Center. She leads the Computational Biology Laboratory, focusing on tumor ecosystem dynamics, cancer genomics, and immuno-informatics. Her research leverages single-cell and spatial multi-omics technologies to dissect cellular heterogeneity, phenotypic plasticity, and therapeutic resistance mechanisms.

• Primary Affiliation: Department of Genomic Medicine, Division of Cancer Medicine, MD Anderson Cancer Center
• Dual Appointment: UTHealth Houston Graduate School of Biomedical Sciences

Research Interests:

• Computational modeling of tumor initiation and progression from premalignant lesions
• Molecular and cellular co-evolution in metastasis
• Therapeutic resistance mechanisms in gastric, ovarian, and pancreatic cancers
• Development of bioinformatics tools for spatial transcriptomics and cellular imaging

Publication Trends: Her recent work spans spatial transcriptomics, single-cell genomics, and immuno-oncology, with a focus on tumor-immune interactions, ferroptosis in immunosuppression, and pathway-targeted therapies for metastatic cancers.

Awards & Grants:

• NIH/NCI R01 Principal Investigator
• NIH/NCI U01 Multiple Principal Investigator
• CPRIT Individual Investigator Research Awards
• Emil Frei, III Award for Translational Research

Leadership & Collaborations: Dr. Wang serves as site Lead of Data Science for Break Through Cancer programs, Co-Director of the GI SPORE Biostatistics Core, and Scientific Editor of Cancer Discovery. She collaborates nationally and internationally on data science-driven cancer research.