معرفی
Lindsay McAlpine, MD is an Assistant Professor in the Department of Neurology at Yale University School of Medicine, specializing in neuroimmunology and neuro-infectious diseases. She founded and directs the NeuroCOVID Clinic at Yale, which treats patients with persistent neurological symptoms following COVID-19 infection, including brain fog, headaches, neuropathy, and cognitive impairment. Her work bridges clinical care with cutting-edge research on the neurological consequences of viral infections.
Dr. McAlpine received her medical degree from Sidney Kimmel Medical College at Thomas Jefferson University in 2017, completed her residency at Yale-New Haven Hospital in 2021, and finished her fellowship training at Yale University in 2023. Her educational background includes a BSc in Environmental Science from Brown University (2009) and a Post-Baccalaureate program at the University of California, Berkeley (2013).
Her research focuses on understanding the neuropathophysiology of Long COVID using advanced imaging techniques, particularly MRI. She investigates how viral infections like SARS-CoV-2 trigger neuroinflammation and lead to persistent neurological symptoms. Her work spans multiple domains including cognitive neuroscience, cerebrovascular circulation, and autoimmune responses in the central nervous system. She employs a comprehensive approach that combines advanced neuroimaging, biomarker testing, and extensive neuropsychological assessments to understand damage to the central, autonomic, and peripheral nervous systems.
Analysis of Dr. McAlpine's recent publications reveals a strong focus on the neurological manifestations of COVID-19, particularly small fiber neuropathy, cognitive impairment, and autonomic dysfunction. Her work demonstrates how advanced MRI techniques can identify biomarkers of cerebral dysfunction in patients with post-COVID cognitive impairment. She has also contributed to understanding the role of autoimmunity in Long COVID and investigated potential therapeutic approaches for post-viral neurological conditions.
- NIMH Grant to advance research into Long COVID and related brain changes (2025)
- Grant to investigate causes of post-COVID-19 neurologic condition (2024)
Dr. McAlpine serves as a sub-investigator for multiple clinical trials related to Long COVID, including 'The Brain Shuttle Study' and research on brain fog in Long COVID patients. She leads the McAlpine Lab, which focuses on understanding the mechanisms that damage the nervous system after COVID-19. Her lab collaborates extensively with the Clinical Neurosciences Imaging Center (CNIC) and the Center for Infection & Immunity at Yale.
The McAlpine Lab conducts research using advanced MRI techniques to study structural, vascular, and functional changes in the brains of Long COVID patients. The lab works with a team including postgraduate associates and collaborates with researchers across Yale University. They recruit research participants both locally and throughout the United States to better understand the impact of Long COVID on the nervous system.
