Linda B. Baughn

Linda B. Baughn, Ph.D., FACMG, serves as a Research Professor in the Department of Laboratory Medicine and Pathology at Mayo Clinic's School of Medicine in Rochester, Minnesota. She co-directs the Clinical Genomics Laboratory and maintains board certification in Clinical Molecular Genetics and Genomics.

Her research program spans translational cancer biology with emphasis on hematologic malignancies, particularly multiple myeloma. Key focus areas include:

• Genomic characterization of structural/copy number variations using next-generation sequencing
• Mechanisms of drug resistance via CyTOF phenotypic profiling
• Racial disparities in myeloma incidence using ancestry-informative genetic markers
• Development of clinical diagnostic approaches for plasma cell disorders

Analysis of her 15 most recent publications reveals predominant themes in cancer genomics (87%), health disparity research (60%), and diagnostic methodology development (53%). Her work consistently bridges basic science with clinical implementation, particularly in myeloma risk stratification.

Key honors include:

• 2017 Clinical Molecular Genetics Certification (ABMGG)
• 2015 Clinical Cytogenetics Certification (ABMGG)
• 2012 AAI Early Career Faculty Travel Grant
• 2006 ASH Travel Award and Leukemia Society Fellowship
• Current roles in AACR Basic Cancer Research Grants Review (2025-2027) and ASH Scientific Committee

Dr. Baughn directs translational research in the Clinical Genomics Laboratory, collaborating extensively with Mayo's Division of Hematology. Her NIH-funded work examines ancestry-related disparities in plasma cell disorders, while her clinical committee work shapes national guidelines for cytogenetic testing in myeloma through the Cancer Genomics Consortium.