Lijie Shi

Lijie Shi is a Researcher in the Department of Genetics at Albert Einstein College of Medicine. Their research focuses on understanding the molecular mechanisms underlying congenital cardiovascular diseases in rare genetic syndromes such as 22q11.2 deletion syndrome (22q11.2 DS) and Miller-Dieker syndrome. They utilize genetically modified mouse models to investigate how the loss of CRK and CRKL genes affects cardiac development, particularly in neural crest cells and endocardial lineages.

Key research interests include developmental biology, molecular mechanisms of congenital heart defects, and the role of signaling pathways in cardiovascular morphogenesis. Shi collaborates extensively with researchers like Dr. BE Morrow, exploring topics such as angiogenesis, heart valve formation, and chromatin regulation in disease contexts.

Publications highlight contributions to understanding how CRK/Crkl proteins regulate early vascular development and their roles in syndromic cardiovascular abnormalities. Their work bridges genetic studies with in vivo model systems to shed light on both basic biology and translational medicine.