معرفی
Lidia Vasilieva is a Professor in the Department of Biochemistry at the University of Oxford and heads the Vasilieva Lab. Her programme integrates biochemistry, structural biology, genetics and genomics to decipher how RNA polymerase II transcription and the RNA exosome machinary jointly control the abundance of individual mRNAs.
Research focus:
- Coupling of mRNA 3′-end formation to the transcription cycle
- Molecular exchange of factors that dislodge Pol II from DNA at termination
- Mechanisms directing select transcripts to the RNA exosome for degradation
By solving high-resolution structures of CTD-interacting domains and RNA-binding modules, her group has revealed how conserved CID-RRM proteins bridge the Pol II C-terminal domain and nascent RNA to ensure accurate co-transcriptional processing. Parallel studies map phosphorylation events that orchestrate factor hand-offs during elongation-to-termination transitions and identify RNA-binding adaptors that recruit the exosome to specific transcripts, thereby shaping cellular transcriptomes in response to environmental cues and developmental programs.
The lab welcomes graduate and post-doctoral applicants and is located in the Dorothy Crowfoot Hodgkin Building, Oxford.
