معرفی
Liam J. Holt is an Associate Professor in the Department of Biochemistry and Molecular Pharmacology at the NYU Grossman School of Medicine. His primary affiliation is with the Institute for Systems Genetics. Dr. Holt holds a PhD from the University of California, San Francisco, and completed a fellowship at the University of California, Berkeley.
His research focuses on understanding how mechanical forces and molecular crowding influence cellular behavior, with particular emphasis on cancer, neurodegeneration, and cell division. Key areas include the regulation of cytoplasmic properties by mTORC1, the impact of physical compression on cancer cell survival, and the biophysical mechanisms underlying neurodegenerative diseases. Holt also leads synthetic biology initiatives, including the creation of synthetic cellular compartments (Syndrops) and the design of synthetic Hox loci to study developmental gene regulation.
His lab, the Holt Lab, employs interdisciplinary approaches combining experimental biology with computational modeling. Current projects include studying genome stability under mechanical stress in pancreatic cancer and glioblastoma, investigating the role of cytoplasmic crowding in aging, and developing synthetic biology tools for precise gene manipulation.
Dr. Holt collaborates extensively with institutions like the NYU Genome Project-Write consortium. His work has been published in top journals including Cell, Nature, and Science. While no specific awards are listed here, his contributions to understanding cellular biophysics and synthetic biology are widely recognized in academic circles.
