Letterio Salvatore Politi

Letterio Salvatore Politi is a Full Professor at Humanitas University, where he serves as Director of the School of Specialization in Diagnostic Radiology and Chair of the Master's Degree in Data Analytics and Artificial Intelligence in Health Sciences (DAIHS). He holds significant international roles as Director of Clinical Affairs at the Advanced MR Imaging Center (AMRIC), University of Massachusetts Medical School, and Director of Neuroimaging Research in the Division of Hematology/Oncology and Radiology Department at Boston Children’s Hospital.

His research focuses on advanced magnetic resonance imaging (MRI) for non-invasive quantification of neurological disease burden. Key areas include quantitative MRI of the brain and spinal cord, lesion load and volumetric analyses, and microstructural damage assessment via diffusion tensor imaging across a spectrum of neurological conditions such as brain tumors, vascular diseases, neuromuscular disorders, and inherited neurodegenerative diseases.

Dr. Politi has authored 67 peer-reviewed scientific publications with an h-index of 26 and over 3,300 citations (Scopus), contributing significantly to translational and clinical neuroimaging. His work includes validating MRI-based outcome measures for clinical trials, central radiological review in international multicenter studies, and the development of integrated multimodal imaging systems like SPECT/MRI. Although specific articles are not listed, his research output demonstrates a consistent focus on imaging biomarkers and advanced neuroimaging methodologies.

• Full Professor, Humanitas University
• Director, School of Specialization in Diagnostic Radiology
• Chair, Master’s in Data Analytics and AI in Health Sciences (DAIHS)
• Director of Clinical Affairs, AMRIC, UMass Medical School
• Director of Neuroimaging Research, Boston Children’s Hospital

Dr. Politi plays a vital role in mentoring and academic leadership through his directorship of residency and master’s programs. While specific grants or funded projects are not detailed, his leadership in core imaging facilities and international trials suggests active grant involvement and research oversight. He is instrumental in advancing clinical MRI research and training the next generation of radiologists and data scientists in health.

He leads neuroimaging research initiatives at Boston Children’s Hospital and directs clinical affairs at the Advanced MR Imaging Center (AMRIC), a core imaging facility at UMass, fostering innovation in imaging technology and its clinical application.