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معرفی
Dr. Lepu Zhou is a Researcher at the Institute of Neuroanatomy, part of the Center for Experimental Medicine within the Faculty of Medicine at Universitätsklinikum Hamburg-Eppendorf (UKE). His research focuses on neurobiology and neuroendocrinology, particularly exploring synaptic plasticity mechanisms, hormonal regulation of neural circuits, and the roles of neurosteroids in brain function. Zhou's work investigates how sex hormones like estrogen influence synaptic connectivity and cognitive processes, with applications to neurodegenerative diseases such as Alzheimer's and ALS.
He investigates molecular pathways involving aromatase enzymes, reelin signaling, and tau protein dysfunction. Key areas of interest include:
- Sex-specific differences in synaptic plasticity
- Neuroprotective mechanisms against neurodegeneration
- Estrogen's role in synaptogenesis and memory formation
- Protein aggregation in tauopathies
Zhou's recent publications (2010–2020) highlight advancements in understanding synaptic modulation by hormones, with studies demonstrating estrogen's critical role in maintaining hippocampal function and synaptic density. His research bridges molecular neuroscience with clinical implications for age-related cognitive decline.
He is affiliated with the Institute of Neuroanatomy's lab groups studying synaptic wiring, neuroinflammation, and neurodegenerative pathologies. Collaborations include work with the European Liquid Biopsy Society (ELBS) on translational neuroscience projects.
